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LMNO was established in 2016 by Natacha Mottart, Christophe Veys, and Olivier Legrain. The gallery aims to bridge the gap between life sciences and contemporary art.

LMNO supports artists whose work fosters dialogue across various fields of knowledge, including science, history, literature, and politics. We showcase artists prioritizing environmental and social issues.

Since June 2021, through the non-profit organisation Ecologisons-nous!, LMNO has been developing an artist residency programme using the Bois de Fa as its playground. The Bois de Fa is a 6.5-hectare experimental garden situated in Grez-Doiceau in Walloon Brabant. It was conceived, planned, developed, built and enriched by a whole team of specialists. The aim of the residency is to foster innovative and experimental artistic projects that can draw inspiration from the spirit of the place, and to explore the possible futures of a humanity that reconciles Nature and Culture.

Since April 2025, the gallery and the non-profit organisation have taken up residence in the toll pavilions at 544 and 589 Avenue Louise.